Each capsule contains : Pantoprazole Sodium Sesquihydrate equivalent to Pantoprazole 40 mg.

(as enteric coated pellets).


Pentrax (Pantoprazole) is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid produ

by covalently binding to (H+ / K+) - ATPase enzyme system at the secretory surface of the gastric parieta

Pentrax is prepared as an enteric-coated pellets so that absorption of Pantoprazole begins only after the ca

leaves the stomach. The absorption of Pantoprazole is rapid, with a Cmax of 2.5 µg/ml that occurs approxim

2.5 hours after oral dose. Following initial oral dose of 40 mg Pantoprazole, a 51% mean inhibition of acid sec

was achieved by 2.5 hours. With once a day dosing for 7 days the mean inhibition was increased to 85%

secretion had returned to normal within a week after the last dose of Pantoprazole. There was no eviden

rebound hypersecretion. Pantoprazole is extensively metabolized in the liver and excreted in urine.


Pentrax is indicated in the following cases:

- Short-term treatment of Erosive Esophagitis associated with Gastroesophageal reflux disease (GERD).

- Maintenance of healing of Erosive Esophagitis.

- Pathological Hypersecretory conditions including Zollinger - Ellison Syndrome.


- Treatment of Erosive Esophagitis : The recommended adult oral dose is 40 mg given once daily for up to

8 weeks and for those patients who have not healed after 8 weeks of treatment, an additional 8 weeks cou

of Pentrax may be considered.

- Maintenance of healing of Erosive Esophagitis : The recommended adult oral dose is one Pentrax capsul

40 mg taken daily.

- Pathological Hypersecretory conditions including Zollinger - Ellison Syndrome : The recommended adult st

dose is 40 mg twice daily. The dose should be adjusted to individual patients needs and should continue f

long as clinically indicated.



Hypersensitivity reaction to Pantoprazole.

Use in Pregnancy & Lactation

There are no adequate and well controlled studies on its use.


Treatment with Pantoprazole may mask symptoms of malignancy and therefore delay diagnosis.


Pantoprazole may interfere with absorption of drugs where gastric pH is an important determinate of their

bioavailability e.g : Ketoconazole, Ampicillin esters and iron salts.


Pantoprazole is well tolerated in both short term and long term trials. Reported adverse effects includes :

headache, diarrhea, flatulence, abdominal pain, rash and eructation. Nausea, vomiting and abnormal liver

function test may appear in long term treatment.


- Store below 30°C in a dry place , protect from light.

- Close the bottle tightly after each use.

- Discard three months from the date of opening.


Pentrax capsules : Pack of 14 capsules.

Pentrax capsules : Strip pack of 10 x10 capsules.