📌 COMPOSITION

Each capsule contains: Omeprazole 20 mg (as enteric coated pellets).

📌 DESCRIPTION

Omezol (Omeprazole) is a proton‑pump inhibitor. It inhibits the secretion of gastric acid by irreversibly blocking the enzyme system of (H+/K+ - ATPase) (the proton pump) in the parietal cells. It inhibits both basal and stimulated acid secretion irrespective of the stimulus. Omeprazole is rapidly absorbed, and its absorption is not affected by food. It is almost completely metabolised in the liver and rapidly eliminated, mostly in the urine. The elimination half‑life is about 0.5 to 3 hours. Omeprazole is highly bound (about 95%) to plasma proteins.

📌 INDICATIONS

Omezol is indicated in the treatment of:

• Gastro‑oesophageal reflux disease.
• Gastric ulcer.
• Duodenal ulcer.
• Zollinger‑Ellison syndrome.
• Reflux oesophagitis.

📌 DOSAGE & ADMINISTRATION

• Gastro‑oesophageal reflux disease: 20 to 40 mg once daily for 4 to 12 weeks. Maintenance therapy: 20 mg once daily.
• Gastric ulcer: 20 mg once daily for 8 weeks. For the prevention of relapse, a maintenance dose of 10-20 mg once daily is recommended.
• Duodenal ulcer: 20 mg once daily for 4 weeks. For the prevention of relapse, a maintenance dose of 10-20 mg once daily is recommended.
• Zollinger‑Ellison syndrome: Long‑term management requires administration of 60 mg up to 120 mg daily of Omezol in divided doses. In some cases, it may require more than 120 mg daily, given in 2 or 3 divided doses.
• Reflux oesophagitis: 20 mg once daily for 4-8 weeks.
• Helicobacter pylori associated peptic ulcer disease: 40-80 mg daily with amoxicillin 1.5 g daily in divided doses for 2 weeks.

📌 RESTRICTIONS ON USE

Contraindications

Hypersensitivity to Omeprazole.

Use in pregnancy and lactation

It is not recommended unless prescribed by a physician.

Precautions

Treatment with Omeprazole may mask symptoms of malignancy and therefore delay diagnosis.

📌 DRUG INTERACTIONS

• Omeprazole can prolong the elimination of diazepam, warfarin and phenytoin.
• It may increase absorption of digoxin and decrease the effectiveness of prednisone.
• Omeprazole inhibits the activity of some hepatic cytochrome P-450 enzymes.

📌 ADVERSE EFFECTS

• Omezol is well tolerated. The most common adverse effects are diarrhoea, skin rash, and headache, which are mild and transient.
• The rare adverse effects include arthralgia, myalgia and blood disturbances.

📌 STORAGE INSTRUCTIONS

• Store below 30°C, protect from light and humidity.
• Close the bottle tightly after each use.
• Discard three months from the date of opening.

📌 PHARMACEUTICAL FORMS

• Omezol 20: Pack of 14 capsules.