COMPOSITION :
Each capsule contains : Tenoxicam B.P. 20 mg.
DESCRIPTION :
Tenoxam 20 (Tenoxicam) is a nonsteroidal anti-inflammatory and analgesic drug which acts by inhibiting prostaglandin synthesis. Its anti-inflammatory effects may be also produced by scavenging or inhibiting the production of active oxygen radicals and by inhibiting leukocyte chemotaxis and phagocytosis. Tenoxicam is well absorbed after oral administration and its peak plasma concentration occurs within 1 to 2.6 hours in fasting subjects and in 4 to 6 hours when it is given with food. It is over 98.5% protein bound and penetrates synovial fluid. The plasma half-life of Tenoxicam is about 60 to 75 hours and it is completely metabolized to inactive metabolites which are excreted mainly in the urine .
INDICATIONS : Tenoxam 20 is indicated in:
- Treatment of osteoarthritis and rheumatoid arthritis, ankylosing spondylitis and gout .
- Treatment of non-articular rheumatism (tendinitis, bursitis, back pain) .
DOSAGE & ADMINISTRATION :
Tenoxam 20 capsules should be swallowed with a full glass of water after meals and at the same time each day.
Adults : Tenoxam 20 is given as a single daily dose of 20 mg. For acute attacks of gouty arthritis the recommended dosage is 40 mg once daily for 2 days followed by 20 mg once daily for a further 5 days.
RESTRICTIONS ON USE : Contraindications
- Known hypersensitivity to the Tenoxicam .
- Patients with active peptic ulcer, active hepatic disease and renal failure . Use in Pregnancy & Lactation Not recommended. Precautions
- Antacids slow the absorption of Tenoxicam.
- Should not be given to patients who will have a surgical procedure.
DRUG INTERACTIONS :
- Tenoxicam may enhance the anticoagulation effect of coumarins.
- Concomitant use of probenecid increases elimination rate of Tenoxicam.
ADVERSE EFFECTS :
Tenoxicam is well tolerated. The major adverse effects include epigastric pain, nausea and indigestion. Less frequent adverse effects include headache and dizziness. The drug should be discontinued if GIT bleeding occurs.
STORAGE INSTRUCTIONS : Store below 30oC protected from light .
PRESENTATIONS :
Tenoxam 20 : Pack of 10 capsules and hospital packs of different sizes .