-

<h4 style="color: #d32f2f;">COMPOSITION</h4>
<p>Each tablet contains: <span style="font-weight: bold;color: #007bff;">Carbamazepine 200mg.</span></p>
<p>Each 5ml of suspension contains: <span style="font-weight: bold;color: #007bff;">Carbamazepine 100 mg.</span></p>

<h4 style="color: #d32f2f;">DESCRIPTION</h4>
<p>Tegrapine (carbamazepine) is an anti-convulsant medicine that prevents fits and can also control mood disorders. It is a sodium channel blocker that inhibits neuron excitation in the brain by reducing glutamate neurotransmitter levels, leading to neuronal membrane stabilization and antiepileptic effects. Its depressant effect on dopamine and noradrenaline turnover may be responsible for its antimanic properties.</p>

<h4 style="color: #d32f2f;">INDICATIONS</h4>
<ul>
    <li>Treatment of epilepsy, including partial seizures with or without secondary generalization and generalized tonic-clonic seizures.</li>
    <li>Treatment of trigeminal neuralgia, a painful condition of the face.</li>
    <li>Control of mood disorders when other medicines do not work.</li>
</ul>

<h4 style="color: #d32f2f;">DOSAGE & ADMINISTRATION</h4>
<p><strong>Adults:</strong> Initially 100-200 mg once or twice daily, increasing gradually to 800-1200 mg daily in divided doses. Maximum dose: 1600-2000 mg if necessary.</p>
<p><strong>Children and adolescents:</strong> 10-20 mg/kg per day in divided doses.</p>
<p><strong>Elderly (65+ years):</strong> Lower doses required, typically starting at 100 mg twice daily.</p>
<p><strong>Trigeminal neuralgia:</strong> Start with 200-400 mg/day, increasing gradually to 600-800 mg/day. Maximum dose: 1200 mg/day.</p>
<p><strong>Mood disorders:</strong> Typically 400-600 mg/day.</p>

<h4 style="color: #d32f2f;">RESTRICTIONS ON USE</h4>
<h4 style="color: #d32f2f;">Contraindications</h4>
<ul>
    <li>Hypersensitivity to carbamazepine, oxcarbazepine, or tricyclic antidepressants.</li>
    <li>Heart problems, history of bone marrow issues, porphyria, or recent use of MAOIs (within 14 days).</li>
</ul>

<h4 style="color: #d32f2f;">Precautions</h4>
<ul>
    <li>Use with caution in patients with impaired sodium metabolism, heart, blood, liver, or kidney disease.</li>
    <li>Not recommended for mixed or absence seizures.</li>
    <li>Genetic testing for HLA-B*1502 is advised for at-risk populations due to the risk of Stevens-Johnson syndrome.</li>
</ul>

<h4 style="color: #d32f2f;">DRUG INTERACTIONS</h4>
<ul>
    <li>Drugs increasing carbamazepine levels: Antituberculars, cardiovascular agents, antidepressants, macrolide antibiotics, and grapefruit.</li>
    <li>Drugs decreasing carbamazepine levels: Phenobarbital, rifampicin, theophylline, isotretinoin, and certain antiepileptics.</li>
    <li>Reduces the efficacy of hormonal contraceptives.</li>
    <li>Increases isoniazid-induced hepatotoxicity.</li>
</ul>

<h4 style="color: #d32f2f;">ADVERSE EFFECTS</h4>
<ul>
    <li>Common: Dizziness, tiredness, nausea, blurred vision, and skin reactions.</li>
    <li>Serious: Leucopenia, fluid retention, weight gain, and blood disorders.</li>
</ul>

<h4 style="color: #d32f2f;">OVERDOSAGE</h4>
<p>Symptoms include CNS depression, agitation, coma, respiratory depression, hypotension, and vomiting. Treatment involves hospitalization, gastric lavage, activated charcoal, and supportive care.</p>

<h4 style="color: #d32f2f;">STORAGE INSTRUCTIONS</h4>
<p>Store below <span style="font-weight: bold;color: #007bff;">30°C</span>, away from light.</p>

<h4 style="color: #d32f2f;">PRESENTATION</h4>
<ul>
    <li>Tegrapine 200 Tablets: Available in different pack sizes.</li>
    <li>Tegrapine suspension: 100 ml pack.</li>
</ul>

COMPOSITION

Each tablet contains: Carbamazepine 200mg.

Each 5ml of suspension contains: Carbamazepine 100 mg.