COMPOSITION :
Ramol Tablets : Each tablet contains Acetaminophen (Paracetamol) USP 500 mg.
Ramol Syrup : Each 5ml contains Acetaminophen (Paracetamol) USP 120 mg or 250mg.
Ramol Suspension : Each 5ml contains Acetaminophen (Paracetamol) USP 120 mg.
Ramol Oral drops : Each 1 ml contains Acetaminophen (Paracetamol) USP 100 mg.
DESCRIPTION :
Ramol (Paracetamol) is a nonopiate, nonsalicylate, analgesic and antipyretic, so it does not
cause GIT irritation. It relieves pain by elevating the pain threshold centrally by blocking
pain-impulse generation through a peripheral action and it reduces the fever by its effect on the
hypothalamic heat regulating center, resulting in peripheral vasodilation , increasing blood
flow through the skin ,sweating and heat loss.The effect of Paracetamol mainly is due to the
inhibition of prostaglandins biosynthesis. Ramol is rapidly absorbed orally, the initial rapid
response occurs in less than half an hour and within 2 hours peak levels are achieved and it is
metabolized in the liver and excreted via the bile and the kidney.
INDICATIONS :
- Children and infants : To relieve fever due to teething, tonsillitis, measles, common cold and
fever after vaccination or immunization.
- Adults : Mild to moderate pain such as headache, back pain, febrile conditions and relieves
discomfort that accompanies cold , flu and sore throat.
Ramol considered the drug of choice for relieving pain and reducing fever in patients with
peptic ulcer, asthma, elderly and children whom NSAIDs or salicylates are contraindicated.
DOSAGE & ADMINISTRATION :
Tablets :
Adults and children above 12 years : 1 - 2 tablets.
Children 6- 12 years : 1/2 - 1 tablet.
Syrup and suspension (120 mg / 5 ml) :
Infants 3 -12 months : 2.5 - 5 ml
Children 1 - 6 years : 5 - 10 ml.
Children 6 - 12 years : 10 - 20 ml.
Syrup (250 mg / 5 ml) :
Children 5 - 8 years : 5 - 7.5 ml .
Children 8 - 10 years : 7.5 - 10 ml :
Children 10 - 12 years : 10 - 12.5 ml.
Adults and children above 12 years : 12.5 - 15 ml.
Oral drops :
Infants 3 - 6 months : 0.5 - 0.75 ml.
Infants 6 months - 1 year : 0.75 - 1 ml.
Children 1 - 2 years : 1 - 1.25 ml*.
* 1.25 ml = (1+ 0.25) ml.
Notes :
- The dose can be taken every 4 - 6 hours, but do not take more than 4 doses in 24 hours. Leave
at least 4 hours between doses. Do not exceed the recommended dose and don’t take for more
than 3 days without consulting doctor.
- The recommended dose for infants 2-3 months of age after vaccination is single dose of 60mg
(2.5ml of (120mg/5 ml ) syrup or suspension or 0.5 ml of oral drops), a second dose can be
given if necessary after 4 - 6 hours of first dose. The recommended dose for infants below
3 months is 10mg/ kg of body weight or 5 mg/ kg of body weight in infants with jaundice.
RESTRICTIONS ON USE :
Contraindications
Hypersensitivity to Paracetamol.
Precautions
Do not take any other products containing Paracetamol. Given with caution to patients with
impaired kidney or liver function.
Use in pregnancy and lactation
There are no effects if Ramol is taken in the recommended doses during pregnancy or
lactation but patients should consult the doctor.
DRUG INTERACTIONS :
- Increase absorption of Paracetamol with Metoclopramide or Domperidone, whereas
absorption reduced by Cholestyramine.
- Prolong regular daily use of Paracetamol enhance anticoagulant effect of warfarin.
SIDE EFFECTS :
Paracetamol is well tolerated when taken in recommended doses. Some allergic reactions like
skin rash may rarely occur.
OVERDOSAGE :
Ingestion of dose exceeding 10g for adults or 150 mg/ kg of body weight for children should
be avoided, it may lead to liver damage. The early symptoms are pallor, nausea, vomiting,
increased sweating, diarrhea, loss of appetite and stomach cramp or pain. Tenderness, pain or
swelling in upper abdominal area may occur 2- 4 days after ingestion the overdose.
Treatment of overdosage : The patient should be given activated charcoal if the overdose
have been ingested within the first hour of ingestion or treated by gastric lavage promptly.
The patient should be given N-acetyl cysteine or methionine within 10 - 12 hours of ingestion
with maintaining fluid and electrolyte balance .
STORAGE INSTRUCTIONS :
Ramol Tablets : Store below 30°C, in a dry place. Protect from light.
Ramol Syrup : Store below 30°C, protect from light & do not refrigerate.
Ramol Suspension : Store below 30°C, protect from light.
Ramol Oral drops : Store below 30°C, protect from light.
PRESENTATIONS :
Ramol Tablets : Pack of 20 tablets and hospital packs of different sizes.
Ramol Syrup : Bottle of 60 ml.
Ramol Suspension : Bottles of 60 ml and 100 ml.
Ramol Oral drops : Bottle of 20 ml.