COMPOSITION :

Each tablet contains : Alprazolam USP 0.25 mg, 0.5 mg & 1.0 mg.

DESCRIPTION :

Prazol (Alprazolam) is an antianxiety and antidepressant agent. Prazol is rapidly absorbed following

oral administration and the peak concentration in the plasma occur within 1 - 2 hours. Alprazolam and

its metabolites are excreted in urine.

INDICATIONS :

Prazol is indicated for the treatment of :

- Anxiety, tension, agitation, insomnia, apprehension and irritability.

- Mixed anxiety depression : symptoms of anxiety and depression occur simultaneously in such patients.

- Neurotic or reactive depression: which appears in patients as depressed mode, loss of pleasure,

symptoms of anxiety, psychomotor agitation, insomnia, appetite disturbances, loss of weight,

cognitive disturbances, feeling of worthlessness or guilt and thoughts of death or suicide.

- Anxiety states, mixed anxiety depression or neurotic depression accompanied with other diseases

such as chronic phase of alcohol withdrawal, and functional or organic disease in particular

gastrointestinal and cardiovascular or dermatological disorders.

DOSAGE & ADMINISTRATION :

- Adults :

Anxiety : Initial dose 0.25 - 0.5 mg three times daily.

(Usual dosage range 0.5 - 4.0 mg daily in divided doses )

Depression : Initial dose 0.5 mg three times daily.

(Usual dosage range 1.5 - 4.5 mg daily in divided doses )

- Debilitated patients and Geriatrics :

Initial dose 0.25 mg two or three times daily, the dose being increased as needed and tolerated.

(Usual dosage range 0.5mg - 0.75mg daily in divided doses)

RESTRICTIONS ON USE :

Contraindications

Hypersensitivity to benzodiazepines.

Precautions

- Possible drowsiness; caution when driving or doing things requiring alertness.

- Avoid sudden abrupt discontinuation of Alprazolam.

- Caution must be taken when giving such drug to patients suffering from renal or hepatic impairment.

Use in pregnancy and lactation

Not recommended.

DRUG INTERACTIONS :

Concomitant use of Alprazolam with barbiturates or alcohol causes additive CNS depressant effect.

SIDE EFFECTS :

- The common side effect is drowsiness.

- Less common side effects are light headedness, blurred vision, nausea, vomiting, diarrhea,

concentration difficulties and confusion.

STORAGE INSTRUCTIONS :

Store below 30°C in a dry place. Protect from light.

PRESENTATIONS :

Prazol 0.25 tablets : Pack of 20 tablets and hospital packs of different sizes .

Prazol 0.5 tablets : Pack of 20 tablets and hospital packs of different sizes .

Prazol 1.0 tablets : Pack of 20 tablets and hospital packs of different sizes .

Mfd. By

P.O. Box : 4265 Sana’a /Yemen.

Council of Arab Health Ministers

Union of Arab Pharmacists

- Medicament is a product which affects your health, and its consumption contrary to instructions is dangerous for you.

- Follow strictly the doctor’s prescription, the method of use and the instructions of the pharmacist who sold the medicament.

- The doctor and the pharmacist are experts in medicine, its benefits and risks.

- Do not by yourself interrupt the period of treatment prescribed for you.

- Do not repeat the same prescription without consulting your doctor.

Keep medicament out of reach of children

012-06-039 9/12

INSTRUCTIONS TO THE PATIENT

Prazol