COMPOSITION :
Each capsule contains : Lansoprazole USP 15, 30 mg (As enteric coated pellets).
DESCRIPTION :
Lanprol (Lansoprazole) suppresses gastric acid secretion by specific inhibition of the H+/ K+-ATPase enzyme
system at the secretory surface of the gastric parietal cells. Lansoprazole is rapidly absorbed after oral
administration and peak plasma concentrations are achieved about 1.5 hrs. Bioavailability is 80% or more even
with the first dose. It is extensively metabolized in the liver and excreted in urine . The plasma half life is
around 1.4 hrs. but the duration of action is much longer . Lansoprazole is about 97% bound to plasma proteins.
INDICATIONS :
Lanprol is indicated in the treatment of :
- Duodenal ulcer ,Gastric ulcer and Acid-related dyspepsia.
- Gastro-oesophageal reflux and Zollinger-Ellison syndrome .
DOSAGE & ADMINISTRATION :
Lanprol is preferred to be taken once daily in the morning before food.
- Duodenal ulcer : 30 mg for 4 weeks. Maintenance dose 15 mg daily .
- Gastric ulcer : 30 mg daily for 8 weeks.
- Acid-related dyspepsia : 15 - 30 mg for 2 - 4 weeks.
- Gastro- oesophageal reflux : 30 mg for up to 8 weeks. Maintenance dose 15 - 30 mg.
- Zollinger-Ellison syndrome : 60 mg once a day . Daily dosage of more than 120 mg should be
administered in divided doses.
RESTRICTIONS ON USE :
Contraindications
Hypersensitivity to Lansoprazole.
Precautions
- Symptomatic response to therapy with Lansoprazole does not preclude the presence of gastric malignancy.
- Consider dose reduction in severe hepatic impairment.
Use in pregnancy and lactation
There are no adequate and well controlled studies on its use.
DRUG INTERACTIONS :
- Lansoprazole may interfere with the absorption of drugs whose bioavailability is dependent on gastric pH as
ketoconazole , ampicillin , iron salts and digoxin.
- Lansoprazole increases the clearance of theophylline.
- Sucralfate delays the absorption and bioavailability of Lansoprazole.
ADVERSE EFFECTS :
Lansoprazole is well tolerated in both short term and long term trials. Reported adverse effects include diarrhea,
abdominal pain , nausea and headache.
STORAGE INSTRUCTIONS :
Store below 30oC , protected from light and humidity.
Close the bottle firmly after each use.
PRESENTATIONS :
Lanprol 15 , 30 : Pack of 14 capsules.
Lanprol 15 , 30 : Strip pack of 10 × 10 capsules.
Lanprol