📌 COMPOSITION

Each tablet contains: Trihexyphenidyl Hydrochloride USP 2 mg or 5 mg.

📌 DESCRIPTION

Kinsol (Trihexyphenidyl Hydrochloride) is a synthetic antispasmodic drug. It acts by inhibition of the parasympathetic nervous system and also has a relaxing effect on smooth muscles. It is well absorbed from the gastrointestinal tract, and it has been stated to exert its action within one hour of oral dose.

📌 INDICATIONS

Kinsol is indicated in the treatment of:

• All forms of parkinsonism (postencephalitic, arteriosclerotic and idiopathic).
• Control of extrapyramidal disorders caused by central nervous system drugs such as phenothiazines, thioxanthenes, butyrophenones and dibenzoxazepines.

📌 DOSAGE & ADMINISTRATION

The dose should be individualised, and elderly patients may require smaller doses.

• Idiopathic parkinsonism: Kinsol is given in 3 or 4 divided doses daily before or with food. The initial dose of 1 mg daily is gradually increased over a period of several days by increments of 2 mg to 6 mg to 10 mg daily according to the response of the patient. 12 mg to 15 mg or more may be required daily in advanced cases. Kinsol can be given with other drugs used for the relief of parkinsonism such as levodopa, but the dose of each may need to be reduced.
• Extrapyramidal symptoms: Usually 5 mg to 15 mg daily, although 1 mg daily may be enough in some cases.

📌 RESTRICTIONS ON USE

Contraindications

Hypersensitivity to the drug.

Precautions

Kinsol should be administered with caution in patients with:

• Cardiac, liver and kidney disorders or with hypertension, glaucoma, obstructive disease of the gastrointestinal or genitourinary tracts, and in elderly males with possible prostatic hypertrophy.
• Geriatric patients, particularly over the age of 60.
• Incipient glaucoma may be precipitated.
• Patients under Trihexyphenidyl HCl therapy must check their intra‑ocular pressure at regular intervals.

Use in Pregnancy and Lactation

Caution should be exercised when administering Kinsol to pregnant and nursing women.

📌 ADVERSE EFFECTS

Minor adverse effects such as dry mouth, blurring of vision, dizziness, mild nausea and nervousness may occur.

📌 DRUG INTERACTIONS

• The effect of Kinsol may be enhanced with other drugs with antimuscarinic properties such as phenothiazines, antihistamines, antipsychotics and tricyclic antidepressants.
• The reduction of gastric motility caused by Kinsol may affect the absorption of other drugs.

📌 STORAGE INSTRUCTIONS

Store below 30°C in a dry place.

📌 PHARMACEUTICAL FORMS

• Kinsol 2 tablets: Pack of 30 tablets and hospital packs of different sizes.
• Kinsol 5 tablets: Pack of 30 tablets and hospital packs of different sizes.