📌 COMPOSITION

Each 5 ml (teaspoonful) contains:

• Chlorpheniramine maleate 1 mg
• Pseudoephedrine HCl 15 mg
• Paracetamol 160 mg
• Dextromethorphan HBr 7.5 mg

📌 DESCRIPTION

Flu Off Plus syrup is an effective formula that contains four active ingredients, including Paracetamol, which is an effective pain reliever and fever reducer acting by inhibiting prostaglandin biosynthesis; Pseudoephedrine, a decongestant that helps to produce vasoconstriction, temporarily reducing the swelling associated with inflammation of the mucous membranes lining the nasal passages; Chlorpheniramine, an antihistaminic agent with anticholinergic action providing a drying effect on the nasal mucosa; and Dextromethorphan HBr, an antitussive.

📌 INDICATIONS

• Treatment of minor and moderate pain and as a fever reducer.
• Relief of cold, flu and allergy symptoms such as nasal and sinus congestion, headache, sneezing, runny nose, and itching of the nose or throat.
• For the symptomatic relief of dry, non‑productive cough.

📌 DOSAGE & ADMINISTRATION

The dose can be taken 2-4 times per day as follows:

• Children 2-5 years: 2.5-5 ml.
• Children 6-12 years: 5-10 ml.

📌 RESTRICTIONS ON USE

Contraindications

• Hypersensitivity to the ingredients.
• Severe liver or kidney disease.
• In patients who are taking or have taken monoamine oxidase inhibitors (MAOIs) for the last two weeks.

Precautions

• Caution should be taken in elderly patients and patients with epilepsy, glaucoma, pyloroduodenal obstruction, diabetes, hypertension, ischaemic heart disease, hyperthyroidism, hepatic impairment, renal dysfunction, prostatic hypertrophy, urinary retention, increased ocular pressure or alcohol dependence.
• Patients with asthma or productive cough, as it may impair the expectoration of secretions.
• Concomitant administration of Flu Off Plus syrup with any product containing Paracetamol should be avoided.

Effects on the ability to drive vehicles or use machines

Flu Off Plus may cause drowsiness; patients should take care during driving or using machines.

Use in Pregnancy and Lactation

There are no studies showing the effect of the drug during pregnancy and lactation, so Flu Off Plus should not be used during pregnancy or lactation unless prescribed by a physician.

📌 DRUG INTERACTIONS

• Co‑administration of Flu Off Plus with metoclopramide may accelerate the absorption of paracetamol, while when given with cholestyramine, the absorption of paracetamol is reduced.
• Alcohol, anxiolytics, MAOIs, tricyclic antidepressants or hypnotics may enhance the sedative effect of Flu Off Plus. Tricyclic antidepressants, MAOIs and other anticholinergic agents may enhance the anticholinergic side effects.
• Co‑administration of Flu Off Plus with oxytocin, beta‑antagonists, guanethidine, methyldopa and MAOIs may increase the risk of hypertension, while concurrent use with ergotamine may increase the risk of ergotism.

📌 SIDE EFFECTS

The most common side effect is drowsiness. There are some minor effects such as headache, dry mouth, blurred vision, gastrointestinal disturbances and skin rash. Very rarely, tinnitus, dizziness or blood disorders have been reported.

📌 OVERDOSAGE

Symptoms of overdosage: Sedation, stimulation of the CNS, convulsions, anticholinergic effects, fast and short breath, high blood pressure, arrhythmia.

Treatment: The patient should be given symptomatic and supportive treatment with monitoring of cardiac, respiratory, renal and hepatic functions and fluid and electrolyte balance. In addition, gastric lavage or induction of emesis should be performed.

📌 STORAGE INSTRUCTIONS

• Store below 30°C; do not refrigerate.
• Protect from light.

📌 PHARMACEUTICAL FORMS

• Flu Off Plus syrup: Bottle of 60 ml.