COMPOSITION :
Each 5 mL contains : Metronidazole Benzoate B.P. equivalent to Metronidazole 100 mg.
Diloxanide Furoate B.P. 125 mg.
Each tablet contains : Metronidazole B.P. 250 mg.
Diloxanide Furoate B.P. 250 mg.
DESCRIPTION :
Flazol Plus is a combination of two drugs with complementary actions: Diloxanide Furoate, a luminal amoebicide
and Metronidazole, a potent tissue amoebicide. Diloxanide Furoate and Metronidazole have synergistic activity.
The combination results in rapid eradication of the parasite and fast clinical cure. Flazol Plus is well tolerated
and provides a comprehensive treatment of both intestinal and extra - intestinal amoebiasis. It is also suitable for
eradication of the parasites in amoeba and giardia cyst passers.
INDICATIONS :
Flazol Plus is indicated for the treatment of :
• Acute amoebic dysentery.
• Chronic intestinal amoebiasis and other systemic infections where Entamoeba histolytica is the causal agent.
• Giardiasis.
• Eradications of amoeba and giardia cyst forms in cyst passers.
DOSAGE & ADMINISTRATION :
Adults : 2 tablets three times daily for 5 - 10 days.
Children : Under 5 years 5ml three times daily for 5 - 10 days.
5 - 12 years 10 ml three times daily for 5 - 10 days.
RESTRICTIONS ON USE :
Contraindications
- Hypersensitivity to imidazole derivatives.
- First trimester of pregnancy.
Precautions
- Administer with caution to patients with CNS disease.
- Administer with caution and reduce the dose in patients with severe liver function impairment.
- In severe kidney impairment 50% of the dose can be given at the usual dosing interval.
Use in pregnancy and lactation
- It is contra-indicated in the first trimester of pregnancy and its use thereafter should be restricted to patients who
showed no benefit from other alternatives.
- Unnecessary exposure of the neonate to the drug should be avoided otherwise breast feeding should be stopped.
ADVERSE EFFECTS :
Nausea, headache, vomiting, constipation, metallic taste, reversible neutropenia, hypersensitivity reactions in the
form of urticaria, erythematous rashes and fever.
STORAGE INSTRUCTIONS :
- Suspension : Store below 25°C , protect from light.
- Tablets : Store below 30°C in a dry place , protect from light.
PRESENTATIONS :
Flazol Plus Tablets : Pack of 30 tablets and hospital packs of different sizes.
Flazol Plus Suspension : Bottle of 100ml.