📌 COMPOSITION

• Each 5 ml contains: Metronidazole Benzoate B.P. equivalent to Metronidazole 100 mg – Diloxanide Furoate B.P. 125 mg.
• Each tablet contains: Metronidazole B.P. 250 mg – Diloxanide Furoate B.P. 250 mg.

📌 DESCRIPTION

Flazol Plus is a combination of two drugs with complementary actions: Diloxanide Furoate, a luminal amoebicide, and Metronidazole, a potent tissue amoebicide. Diloxanide Furoate and Metronidazole have synergistic activity. The combination results in rapid eradication of the parasite and fast clinical cure. Flazol Plus is well tolerated and provides a comprehensive treatment of both intestinal and extra‑intestinal amoebiasis. It is also suitable for eradication of the parasites in amoeba and giardia cyst passers.

📌 INDICATIONS

Flazol Plus is indicated for the treatment of:

• Acute amoebic dysentery.
• Chronic intestinal amoebiasis and other systemic infections where Entamoeba histolytica is the causal agent.
• Giardiasis.
• Eradication of amoeba and giardia cyst forms in cyst passers.

📌 DOSAGE & ADMINISTRATION

• Adults: 2 tablets three times daily for 5-10 days.
• Children 5-12 years: 10 ml three times daily for 5-10 days.
• Children under 5 years: 5 ml three times daily for 5-10 days.

📌 RESTRICTIONS ON USE

Contraindications

• Hypersensitivity to imidazole derivatives.
• First trimester of pregnancy.

Precautions

• Administer with caution to patients with CNS disease.
• Administer with caution and reduce the dose in patients with severe liver function impairment.
• In severe kidney impairment, 50% of the dose can be given at the usual dosing interval.

Use in pregnancy and lactation

• It is contra‑indicated in the first trimester of pregnancy and its use thereafter should be restricted to patients who showed no benefit from other alternatives.
• Unnecessary exposure of the neonate to the drug should be avoided, otherwise breast‑feeding should be stopped.

📌 ADVERSE EFFECTS

Nausea, headache, vomiting, constipation, metallic taste, reversible neutropenia, hypersensitivity reactions in the form of urticaria, erythematous rashes and fever.

📌 STORAGE INSTRUCTIONS

• Suspension: Store below 25°C, protect from light.
• Tablets: Store below 30°C in a dry place, protect from light.

📌 PHARMACEUTICAL FORMS

• Flazol Plus Tablets: Pack of 30 tablets and hospital packs of different sizes.
• Flazol Plus Suspension: Bottle of 100 ml.