📌 COMPOSITION

Despasm:

Each F/C tablet contains: Mebeverine HCl B.P. 135 mg.

Despasm Retard:

Each Capsule contains: Mebeverine HCl 200 mg (as sustained release pellets).

📌 DESCRIPTION

Despasm (Mebeverine HCl) is an antispasmodic with direct action on the smooth muscle of the gastro‑intestinal tract. Its action is not mediated by the autonomic nervous system and the anticholinergic side effects do not occur. It is completely metabolised by hydrolysis and the metabolites are excreted in the urine. Despasm tablets are rapidly absorbed after oral doses with peak plasma concentrations occurring in 1 to 3 hours and 75% of Mebeverine bound to albumin in plasma. Despasm Retard capsules are a prolonged release formulation.

📌 INDICATIONS

• Symptomatic treatment of abdominal pain and cramps.
• Intestinal discomfort related to irritable bowel syndrome.
• Gastro‑intestinal spasm.

📌 DOSAGE AND ADMINISTRATION

Despasm tablets: The usual dose is one tablet three times daily, taken 20 minutes before meals with water.

Despasm Retard capsules: The usual dose is one capsule twice daily (morning and evening).

📌 RESTRICTIONS ON USE

Contraindications

Hypersensitivity to Mebeverine.

Effects on the capacity to drive vehicles or use machines

Occasionally, Mebeverine may cause dizziness which may affect the ability to drive vehicles or use machines.

Use in pregnancy and lactation

It should be administered with caution during pregnancy. Mebeverine is not excreted in the milk of lactating women after therapeutic doses.

📌 ADVERSE EFFECTS

In general, Mebeverine is well tolerated. In very rare cases, allergic reactions such as exanthem or urticaria, and dizziness have been reported.

📌 OVERDOSAGE

Mebeverine may cause CNS excitability in case of overdosage. Gastric lavage and symptomatic treatment is recommended.

📌 STORAGE INSTRUCTIONS

• Despasm Tablets: Store below 30°C in a dry place. Protect from light.
• Despasm Retard Capsules: Store below 30°C in a dry place. Protect from light.

📌 PHARMACEUTICAL FORMS

• Despasm Tablets: Blister pack of 20 tablets and hospital packs of different sizes.
• Despasm Retard Capsules: Blister pack of 20 capsules and hospital packs of different sizes.