COMPOSITION :

Each 5 ml contains : Chlorpheniramine Maleate USP 2.5 mg.

Each tablet contains : Chlorpheniramine Maleate USP 4 mg.

DESCRIPTION :

Histat (Chlorpheniramine Maleate) is a histamine H1-receptor antagonist belonging to the alkylamine

class. It is considered one of the most effective and least toxic of the histamine antagonists. It

antagonizes many of the pharmacological actions of histamine. It prevents the dilatation and

increased permeability produced by histamine on the capillaries. It has a duration of 4 - 6 hours.

INDICATIONS :

Histat is indicated for the treatment of :

- Allergic manifestations such as vasomotor rhinitis and hay fever.

- Spasmodic bronchial cough without dyspnea. It can be useful as a complete alternative for cough

preparations at night.

- Urticaria and angioneurotic edema.

- Motion sickness.

- Pruritis ani and vulvae.

- Atopic and contact dermatitis and insect bites.

DOSAGE & ADMINISTRATION :

Adults and children over 12 years : 5 - 10 ml or 1 tablet three or four times daily.

Children 6 - 12 years : 2.5 - 5 ml three or four times daily.

Children 1 - 6 years : 2.5 ml three or four times daily.

Children up to 1 year : 2.5 ml twice daily.

RESTRICTIONS ON USE :

Contraindications

Hypersensitivity to Chlorpheniramine Maleate.

Precautions

- Patients should be warned about possible additive effects with alcohol and central nervous system

depressants (hypnotics, sedatives, tranquilizers).

- Administer with caution upon driving vehicles or operating machinery since it may cause drowsiness.

Use in pregnancy and lactation

Administer under medical supervision.

DRUG INTERACTIONS :

Concomitant administration with alcohol & sedative drugs will potentiate the sedative effects of

Chlorpheniramine Maleate.

SIDE EFFECTS :

- Slight to moderate drowsiness is the most frequent side effect.

- Others : include hypotension, headache, drowsiness, fatigue, blurred vision, loss of appetite,

nausea, vomiting and dry mouth.

STORAGE INSTRUCTIONS :

Syrup : Store below 25°C, protect from light.

Tablets : Store below 25°C in a dry place , protect from light.

PRESENTATIONS :

Histat Syrup : Bottle of 60 ml and 100 ml.

Histat Tablets : Pack of 20 tablets and hospital packs of different sizes.