Section :
CLARIN
COMPOSITION :
Each tablet contains : Loratadine USP 10 mg.
Each 5ml (teaspoonful) syrup contains : Loratadine USP 5 mg.
DESCRIPTION :
Clarin contains loratadine is a potent long acting tricyclic antihistamine with selective peripheral
H1-receptor antagonistic nonsedative activity. It also blocks histamine-induced
bronchoconstruction and hence used as antiasthmatic. Clarin is well and rapidly absorbed from
the gastrointestinal tract after oral administration. An antihistaminic effect beginning within
1- 3 hours, reaching a maximum at 8 -12 hours and the duration of action is at least 24 hours.
INDICATIONS :
Clarin is indicated for :
- Relief of symptoms associated with allergic rhinitis such as sneezing, nasal discharge and itching
as well as ocular itching and burning .
- Relief of symptoms and signs of chronic urticaria and other allergic dermatologic disorder.
- Treatment adjunct in asthma.
- Treatment adjunct for anaphylactic and anaphylactoid reactions.
DOSAGE & ADMINISTRATION :
- Adults and children 12 years of age and over :
10 mg (one tablet) of clarin tablet or (two teaspoonful) of Clarin syrup once daily.
- Children 2 to 12 years of age :
For body weight > 30 kg : 10 mg (two teaspoonful) Clarin syrup once daily.
For body weight ≤ 30 kg : 5 mg (one teaspoonful) Clarin syrup once daily.
RESTRICTIONS ON USE :
Contraindications
It is contraindicated in patients with hypersensitivity or idiosyncrasy to the product.
Precautions
- The initial dose should be decreased with patients with severe liver impairment as clearance of
Loratadine may be reduced, an initial dose of 5mg once daily or 10mg every other day is
recommended.
- Safety and efficacy of Loratadine in children younger than two years of age have not yet been
established .
Use in pregnancy and lactation
- Use during pregnancy just if clearly needed since its safety has not been established.
- Not recommended during lactation.
ADVERSE EFFECTS :
Mild and rare and comparable to placebo such as fatigue, sedation, headache and nervousness.
STORAGE INSTRUCTIONS :
Tablets : Store between 2 - 30°C , in a dry place.
Syrup : Store between 2 - 30°C.
PRESENTATIONS :
Clarin Tablets : Pack of 10 tablets and hospital packs of different sizes.
Clarin Syrup : bottle of 100ml.
