📌 COMPOSITION

• Each 5 ml syrup contains: Ketotifen Fumarate equivalent to Ketotifen 1 mg.
• Each tablet contains: Ketotifen Fumarate equivalent to Ketotifen 1 mg.

📌 DESCRIPTION

Zatin (Ketotifen) is an antiasthmatic drug with marked antianaphylactic properties and a specific antihistaminic effect. Its antiasthmatic activity is attributed to a number of factors including inhibition of phosphodiesterases, inhibition of PAF-induced accumulation of eosinophils in the airways, inhibition of the release of histamine and leukotrienes, and functional antagonism of the effects of leukotrienes. Ketotifen is almost completely absorbed after oral administration. Bioavailability is approximately 50% due to a first-pass effect in the liver. Peak plasma concentration is achieved within 2-4 hours. Protein binding is 75%. Ketotifen is eliminated biphasically with a short half-life of 3-5 hours and a longer one of 21 hours. 70% is excreted in urine as metabolites.

📌 INDICATIONS

Zatin is indicated in:

• Long-term prevention of bronchial asthma, allergic bronchitis and asthmatic symptoms associated with hay fever.
• Prevention and treatment of multisystemic allergies, allergic rhinitis and allergic dermatoses.

📌 DOSAGE & ADMINISTRATION

Zatin is administered with meals as follows:

• Adults and children over 12 years: 1 tablet twice daily; may be increased if necessary to 2 tablets twice daily. If drowsiness is likely to be a problem, a dose of 0.5-1 tablet is given with the evening meal.
• Children over 3 years: 5 ml of syrup twice daily.
• Children from 6 months to 3 years: 2.5 ml of syrup twice daily.

(It may take several weeks for Zatin to achieve its full effect in preventing asthmatic attacks.)

📌 RESTRICTIONS ON USE

Contraindications

Hypersensitivity to Ketotifen.

Precautions

• Use with caution in patients with prostatic hypertrophy, urinary retention, susceptibility to angle-closure glaucoma, or pyloroduodenal obstruction.
• Effects on the ability to drive vehicles and use machines: Caution should be observed when taking Zatin as it may cause drowsiness.
• Use in Pregnancy & Lactation: Usage should be avoided in pregnancy and lactation unless highly recommended by the doctor and the benefits outweigh the potential risks.

📌 DRUG INTERACTIONS

• Concomitant use with oral antidiabetic agents may lead to a reversible fall in platelet count.
• Concomitant use with sedatives, hypnotics, antihistamines, and alcohol may potentiate their effects.

📌 ADVERSE EFFECTS

• Common: Drowsiness.
• Less common: Dryness of the mouth and slight dizziness at the beginning of treatment, but normally disappear quickly. Increased appetite and weight gain have been reported.

📌 STORAGE INSTRUCTIONS

• Syrup: Store below 30°C.
• Tablets: Store below 30°C in a dry place.

📌 PHARMACEUTICAL FORMS

• Zatin Syrup: Bottle of 100 ml.
• Zatin Tablets: Pack of 20 tablets and hospital packs of different sizes.