📌 COMPOSITION

• Ramol Tablets: Each tablet contains Acetaminophen (Paracetamol) USP 500 mg.
• Ramol Syrup: Each 5 ml contains Acetaminophen (Paracetamol) USP 120 mg or 250 mg.
• Ramol Suspension: Each 5 ml contains Acetaminophen (Paracetamol) USP 120 mg.
• Ramol Oral drops: Each 1 ml contains Acetaminophen (Paracetamol) USP 100 mg.

📌 DESCRIPTION

Ramol (Paracetamol) is a non-opiate, non-salicylate analgesic and antipyretic, so it does not cause GIT irritation. It relieves pain by elevating the pain threshold centrally by blocking pain-impulse generation through a peripheral action, and it reduces fever by its effect on the hypothalamic heat-regulating center, resulting in peripheral vasodilation, increasing blood flow through the skin, sweating and heat loss. The effect of Paracetamol is mainly due to the inhibition of prostaglandin biosynthesis. Ramol is rapidly absorbed orally; the initial rapid response occurs in less than half an hour and within 2 hours peak levels are achieved. It is metabolized in the liver and excreted via the bile and kidneys.

📌 INDICATIONS

• Children and infants: To relieve fever due to teething, tonsillitis, measles, common cold, and fever after vaccination or immunization.
• Adults: Mild to moderate pain such as headache, back pain, febrile conditions, and relieves discomfort that accompanies cold, flu, and sore throat.
• Ramol is considered the drug of choice for relieving pain and reducing fever in patients with peptic ulcer, asthma, the elderly, and children for whom NSAIDs or salicylates are contraindicated.

📌 DOSAGE & ADMINISTRATION

Tablets

• Adults and children over 12 years: 1-2 tablets.
• Children 6-12 years: ½ - 1 tablet.

Syrup and suspension (120 mg / 5 ml)

• Infants 3-12 months: 2.5 - 5 ml.
• Children 1-6 years: 5 - 10 ml.
• Children 6-12 years: 10 - 20 ml.

Syrup (250 mg / 5 ml)

• Children 5-8 years: 5 - 7.5 ml.
• Children 8-10 years: 7.5 - 10 ml.
• Children 10-12 years: 10 - 12.5 ml.
• Adults and children over 12 years: 12.5 - 15 ml.

Oral drops

• Infants 3-6 months: 0.5 - 0.75 ml.
• Infants 6 months - 1 year: 0.75 - 1 ml.
• Children 1-2 years: 1 - 1.25 ml (1.25 = 1 + 0.25 ml).

Notes:

• The dose can be taken every 4-6 hours, but do not take more than 4 doses in 24 hours. Leave at least 4 hours between doses. Do not exceed the recommended dose and do not take for more than 3 days without consulting a doctor.
• The recommended dose for infants 2-3 months of age after vaccination is a single dose of 60 mg (2.5 ml of 120 mg/5 ml syrup or suspension, or 0.5 ml of oral drops). A second dose may be given if necessary after 4-6 hours of the first dose. The recommended dose for infants below 3 months is 10 mg/kg body weight or 5 mg/kg body weight in infants with jaundice.

📌 RESTRICTIONS ON USE

Contraindications

Hypersensitivity to Paracetamol.

Precautions

• Do not take any other products containing Paracetamol. Administer with caution to patients with impaired kidney or liver function.

Use in Pregnancy and Lactation

There are no adverse effects if Ramol is taken in the recommended doses during pregnancy or lactation, but patients should consult their doctor.

📌 DRUG INTERACTIONS

• Absorption of Paracetamol is increased with Metoclopramide or Domperidone, whereas absorption is reduced by Cholestyramine.
• Prolonged regular daily use of Paracetamol enhances the anticoagulant effect of warfarin.

📌 SIDE EFFECTS

Paracetamol is well tolerated when taken in recommended doses. Some allergic reactions such as skin rash may rarely occur.

📌 OVERDOSAGE

Ingestion of a dose exceeding 10 g for adults or 150 mg/kg body weight for children should be avoided, as it may lead to liver damage.

Early symptoms: Pallor, nausea, vomiting, increased sweating, diarrhea, loss of appetite, and stomach cramps or pain. Tenderness, pain, or swelling in the upper abdominal area may occur 2-4 days after overdose ingestion.

Treatment of overdosage: Administer activated charcoal within the first hour of ingestion or perform gastric lavage promptly. Administer N-acetylcysteine or methionine within 10-12 hours of ingestion, while maintaining fluid and electrolyte balance.

📌 STORAGE INSTRUCTIONS

• Ramol Tablets: Store below 30°C in a dry place, protect from light.
• Ramol Syrup: Store below 30°C, protect from light, do not refrigerate.
• Ramol Suspension: Store below 30°C, protect from light.
• Ramol Oral drops: Store below 30°C, protect from light.

📌 PHARMACEUTICAL FORMS

• Ramol Tablets: Pack of 20 tablets and hospital packs of different sizes.
• Ramol Syrup: Bottle of 60 ml.
• Ramol Suspension: Bottles of 60 ml and 100 ml.
• Ramol Oral drops: Bottle of 20 ml.