📌 COMPOSITION

• Each 5 ml (reconstituted suspension) contains: Erythromycin Ethyl Succinate equivalent to Erythromycin 125 mg, 200 mg or 250 mg.
• Each F/C tablet contains: Erythromycin Stearate equivalent to Erythromycin 250 mg or 500 mg.

📌 DESCRIPTION

Erythrosan (Erythromycin) is a macrolide antibiotic with a primarily bacteriostatic action against a broad range of bacteria including Gram‑positive bacteria such as Streptococcus pneumoniae, Streptococcus pyogenes and most strains of Staphylococcus aureus, Bacillus anthracis, Corynebacterium diphtheriae and Clostridium spp., Gram‑negative bacteria such as Neisseria, Moraxella, H. influenzae, Actinomyces, Chlamydia, Rickettsias, Treponema pallidum. Erythromycin is adequately absorbed after oral administration. Peak plasma concentrations occur between 1 and 4 hours. Erythromycin is widely distributed throughout body tissues and fluids with a high concentration in the liver and spleen. It is mainly excreted in the bile. Erythromycin crosses the placenta and is excreted in breast milk.

📌 INDICATIONS

Erythrosan is indicated in the treatment of infections caused by susceptible microorganisms as:

• Eye infections: blepharitis.
• Ear infections: otitis media, otitis externa, mastoiditis.
• Oral infections: gingivitis, Vincent's angina, dental infections.
• Respiratory tract infections: tonsillitis, pharyngitis, laryngitis, sinusitis, secondary infections in colds and influenza, tracheitis, acute and chronic bronchitis, pneumonia (including Mycoplasma pneumonia).
• Gastro‑intestinal tract infections: cholecystitis, staphylococcal enterocolitis, intestinal amebiasis (Entamoeba histolytica).
• Skin and soft tissue infections: boils, abscesses, pustular acne, impetigo.
• Prophylaxis: pre‑ and post‑operative, trauma, burns, rheumatic fever.
• Other infections: diphtheria, scarlet fever, urethritis, gonorrhoea, syphilis and lymphogranuloma venereum.

📌 DOSAGE AND ADMINISTRATION

• Children up to 2 years: 125 mg every 6 hours.
• Children 2-8 years: 200-250 mg every 6 hours and may be doubled for severe infections.
• Adults and children over 8 years: 250-500 mg every 6 hours or 0.5-1 g every 12 hours and up to 4 g daily in severe infections.
• Early syphilis: 500 mg 4 times daily for 14-21 days.
• Non‑gonococcal urethritis: 500 mg 2-4 times daily for 7-14 days.

📌 RESTRICTIONS ON USE

Contraindications

• Erythromycin is contraindicated in patients with known hypersensitivity to the drug.
• Erythromycin is contraindicated in patients taking terfenadine.

Precautions

• As with other erythromycins, caution should be exercised in patients with existing liver diseases or impaired hepatic function.
• Use with care in patients with a history of arrhythmias.

Use in Pregnancy and Lactation

Use erythromycin in pregnant women only if clearly needed, and exercise caution when administering to nursing women.

📌 DRUG INTERACTIONS

Concomitant administration of Erythromycin with the following drugs may increase the potentiality or the toxicity of these drugs because of its effect on the cytochrome P-450: Alfentanil, Astemizole, Bromocriptine, Theophylline, Digoxin, Warfarin, Ergotamine, Triazolam, and Terfenadine.

📌 ADVERSE EFFECTS

The most frequent side effects are nausea, vomiting, abdominal discomfort, diarrhoea, urticaria, rashes, and allergic reactions.

📌 STORAGE INSTRUCTIONS

• Dry powder: Store below 30°C in a dry place.
• Reconstituted suspension: Store in a refrigerator and use within 10 days.
• Tablets: Store below 30°C in a dry place.

📌 PHARMACEUTICAL FORMS

• Erythrosan Powder for oral suspension 125, 200 or 250 mg: Bottle of 100 ml (after reconstitution).
• Erythrosan F/C Tablets: Pack of 20 tablets and hospital packs of different sizes.