📌 COMPOSITION

Each capsule contains: Doxycycline hyclate USP equivalent to 100 mg doxycycline.

📌 DESCRIPTION

Doxin (doxycycline hyclate) is a synthetically derived tetracycline with bacteriostatic properties against a broad spectrum of bacteria and also some antiprotozoal properties. It acts by inhibiting protein synthesis in these organisms. Doxycycline is highly absorbed from the GIT. Its absorption is not affected by food. It is bound to plasma proteins by 80-95% and is widely distributed in the body tissues and fluids. It is excreted in faeces, and its half‑life in plasma is 15-25 hours.

📌 INDICATIONS

• Respiratory tract infections: pneumonia particularly that caused by mycoplasma.
• Laryngitis and sinusitis.
• Gastroenteritis caused by Shigella, E. coli and Cholera.
• Urinary tract infections.
• Syphilis (Treponema pallidum), Gonorrhoea (Neisseria), lymphogranuloma inguinale and granuloma inguinale.
• Pelvic inflammatory disease in women.
• Epididymitis, orchitis and nongonococcal urethritis (caused by chlamydia).
• Acne vulgaris.
• Malta fever, spotted fever, typhus fever, Q fever and remittent fever.
• As an adjunct in the treatment of malignant Plasmodium falciparum malaria.
• In the treatment of trachoma.

📌 DOSAGE & ADMINISTRATION

Doxin capsules should be swallowed with plenty of fluid in the sitting or standing position.

• Mild to moderate infections: 100 mg twice daily for the first day, followed thereafter by 100 mg once daily.
• Severe infections: 100 mg twice daily.

📌 RESTRICTIONS ON USE

Contraindications

Hypersensitivity to tetracyclines.

Precautions

• Should be avoided in children below 8 years due to the risk of permanent teeth discolouration and the formation of a stable calcium compound in the bone‑forming tissues.
• Monitoring hepatic and renal functions is advisable.

Use in Pregnancy and Lactation

Not recommended during pregnancy and lactation except after consulting the physician.

📌 DRUG INTERACTIONS

• The absorption of tetracyclines is impaired by antacids containing aluminium, calcium, magnesium or bismuth. Thus, antacids should be taken 2 hours before or after tetracycline administration.
• Sodium bicarbonate decreases the absorption of tetracyclines.
• Cimetidine decreases the absorption of tetracyclines.
• Tetracyclines decrease insulin demand.
• Tetracyclines decrease the efficacy of oral contraceptives.
• Tetracyclines increase the serum levels of digoxin and lithium.
• Tetracyclines increase the serum levels of oral anticoagulants and thus decrease prothrombin level significantly.

📌 ADVERSE EFFECTS

Nausea, vomiting, diarrhoea, erythema and photosensitivity.

📌 STORAGE INSTRUCTIONS

Store below 30°C in a dry place. Protect from light.

📌 PHARMACEUTICAL FORMS

• Doxin Capsules: Pack of 10 capsules and hospital packs of different sizes.