📌 COMPOSITION

Each film‑coated tablet contains: Dapoxetine HCl equivalent to Dapoxetine 30 mg, 60 mg.

📌 DESCRIPTION

Dapoxin (Dapoxetine) is a drug specialised to treat premature ejaculation. It works by inhibiting serotonin reuptake in the brain; it belongs to antidepressant drugs that have a perfect efficiency for treating premature ejaculation related to anxiety and depression disturbances. If there is a low effect or irregular release of serotonin, this may cause sexual anxiety; dapoxetine increases the effect of serotonin and regulates its release. Any drug that works on serotonin regulation in the brain needs two weeks to a month to reach the effective concentration in the blood and needs the same time or longer to eliminate its effect from the body, while Dapoxin has a unique fast and temporary effect because it is absorbed very fast and needs only two hours to reach the effective concentration in the blood and needs less than 24 hours to eliminate its effect from the body. Thus, Dapoxin permits its use when needed without the obligation of a continuous dose. Dapoxin increases the erectile time before ejaculation and can improve control over ejaculation, and this reduces the feeling of frustration and worry.

📌 INDICATIONS

Basically, it is used to treat premature ejaculation in adult men aged 18 to 64 years.

📌 DOSAGE & ADMINISTRATION

• The recommended dose is 30 mg; it may be increased to the maximum dose of 60 mg, and it should be taken 1 to 3 hours before sexual activity. Swallow the tablet with at least one full glass of water.
• This medicine can be taken with or without food. Do not take Dapoxin more than once every day.
• This medicine should not be used by men under 18 or over 65 years of age.

📌 RESTRICTIONS ON USE

Contraindications

Dapoxin should not be used for persons suffering from:

• Allergy (hypersensitivity) to dapoxetine.
• Heart problems, such as heart failure or problems with heart rhythm.
• History of syncope or moderate or severe liver problems (hepatic impairment).
• Severe depression or mania (symptoms include feeling over‑excited, irritable or not being able to think clearly).

Precautions

Caution should be taken and consult the physician in the following cases:

• Patients who have not been diagnosed with premature ejaculation or patients suffering from another sexual problem, such as erectile dysfunction.
• Swallow the tablet with at least one full glass of water to reduce fainting and lowering of blood pressure. If the patient is dehydrated, taking Dapoxin should be avoided (especially if he did not take any drink in the past 4-6 hours, has been sweating for a long time, has a high temperature or diarrhoea). In case of feeling dizzy or tired, the patient should lie down immediately so that the head level is lower than the rest of the body. Also, the patient should not stand up suddenly after a long time of sitting or lying down.
• History of dizziness from low blood pressure on standing (orthostatic hypotension).
• Using recreational drugs such as ecstasy (methylene dioxymethamphetamine), LSD (lysergic acid diethylamide), narcotics or benzodiazepines.
• Mental health problems (such as depression, mania, bipolar disorder or schizophrenia), epilepsy, history of bleeding or blood clotting problems, kidney problems, risk of high pressure in the eye (glaucoma).
• Stop taking Dapoxin and consult the doctor immediately in case of seizures, fainting, change in mood or suicidal thinking.

Use in Pregnancy and Lactation

Dapoxin should not be taken by women.

Effects on the ability to drive vehicles or use machines

Caution should be taken because Dapoxin may cause sleepiness, dizziness, fainting, difficulty concentrating and blurred vision. If these symptoms appear, you should not drive or use machines.

📌 DRUG INTERACTIONS

• Concomitant use of Dapoxin with the following medicines should be avoided:
  • Medicines for depression called “monoamine oxidase inhibitors” (MAOIs), thioridazine, other medicines for depression, lithium, linezolid, tryptophan, St John’s wort, tramadol and medicines used to treat migraine.
• Note: After finishing the above medicines, wait two weeks before starting Dapoxin. Also, wait one week after finishing Dapoxin before starting these medicines.
• Medicines used to treat fungal infections (ketoconazole, itraconazole), medicines used to treat AIDS (ritonavir, saquinavir, nelfinavir and atazanavir), telithromycin (antibiotic) and nefazodone.
• Caution should be taken when Dapoxin is co‑administered with the following medicines:
  • Any medicines that act in the brain that are not used to treat depression.
  • Sildenafil, tadalafil, vardenafil, verapamil, diltiazem and medicines used to treat prostate enlargement, because these medicines may lower blood pressure, especially on standing.
  • Ibuprofen, aspirin, warfarin, fluconazole, erythromycin, clarithromycin, amprenavir, fosamprenavir and aprepitant.

📌 SIDE EFFECTS

Side effects may appear due to taking Dapoxin; not every person gets them.

• Very common: Dizziness, headache and feeling sick.
• Common: Feeling irritable, anxious, agitated or restless, feeling numb, having pins and needles, difficulty in erection, increased sweating, flushing, diarrhoea, constipation, gas, stomach pain, difficulty in sleeping or strange dreams, nightmares, somnolence, yawning, nasal congestion, a rise in blood pressure, difficulty concentrating, trembling, ringing in the ears, blurred vision, indigestion and dry mouth.

📌 OVERDOSAGE

• Symptoms of overdosage: Nausea, vomiting, tremor, dizziness, somnolence, tachycardia.
• Treatment: Supportive care and treatment of symptoms is recommended.

📌 STORAGE INSTRUCTIONS

Store below 30°C in a dry place.

📌 PHARMACEUTICAL FORMS

• Dapoxin 60: Pack of different sizes.
• Dapoxin 30: Pack of different sizes.